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Title: Mutational analysis of protein:protein and protein:small molecule interactions
Author: Derome, Andrew Alexander
ISNI:       0000 0001 3422 6663
Current Institution: University of Manchester
Date of Award: 2003
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Transcription factors of the NFkB family are dimers that have the abihty to bind to DNA sequences in a specific way to target sites which are the enhancers of genes important in the growth process and the immune system, either activating or repressing the transcription and hence the expression of the gene. Therefore, the therapeutic possibilities that the family offers appear to be appreciable: by controlling the binding of the DNA, it would be possible to control DNA transcription (by on/off gene switching). This was the aim of this project.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available