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Title: Heat shock protein 90 (Hsp90) and infection due to Cryptcoccus neoformans
Author: Alakeel, Raid Abdulrahman
ISNI:       0000 0001 3409 6854
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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Cryptococcus neofomans causes up to 80% of cryptococcal meningitis cases in HIV positive individuals, resulting in significant morbidity and mortality within this patient group. Heat-shock proteins (Hsps) are a group of proteins play vital functions in the folding and unfolding or translocation of proteins, as well as in the assembly and disassembly of protein complexes. Many heat-shock proteins have been identified in fungi, such as Hsp70 in C. neoformans and Hsp90 in C. albicans. Mycograb® is a recombinant antibody derived against the LKVIRKNIV epitope of candidal Hsp90. In the present thesis, anti-Hsp90 polyclonal antibody was used in the immunoelectron microscopy and immunoblot assays to demonstrate the cellular localization and induction of Hsp90 in C. neoformns under various stress factors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available