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Title: Population pharmacokinetic-pharmacodynamic modelling and optimal experimental design of Ro115-1240 in healthy subjects and stress urinary incontinence patients
Author: Majid, Oneeb
ISNI:       0000 0001 3617 0579
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Stress urinary incontinence (SUI) is a distressing condition characterised by urine leakage upon physical effort, coughing or sneezing and may affect up to half of adult women. Despite this there are no globally approved pharmacotherapies. A common approach is the targeting of lower urinary tract (LUT) α₁-adrenoceptors, which however can lead to unwanted increases in blood pressure and reflex bradycardia.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available