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Title: In vivo tumour perfusion studies using positron emission tomography : relevance and implications for quality assurance
Author: Laking, George Robert
ISNI:       0000 0001 3604 0336
Current Institution: University of Manchester
Date of Award: 2008
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Using [¹⁵O]-water pet it is possible to estimate tumour vascular physiological parameters including blood flow and the volume of distribution of water. My project investigated the way in which vascular physiology could be modified by anticancer treatments of (1) cytostatic and (2) cytotoxic nature. This thesis reports a series of studies using positron emission tomography (pet) and water labelled with radioactive oxygen-15. I also report some results with the tracers [¹⁵O]-carbon monoxide, [¹¹c]-thymidine and [11c]-bicarbonate. In practice, the studies revealed unanticipated potential for error in the methods used. Therefore this thesis has focused in large part on quality assurance of [¹⁵O]-water pet methods as used by the clinician researcher.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available