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Title: Molecular mechanisms of the gut immune systems and effects on nutrient sensing cells
Author: Worthington, John Joseph
ISNI:       0000 0001 2427 5883
Awarding Body: Manchester University
Current Institution: University of Manchester
Date of Award: 2008
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The nematode Trichinella spiralis produces a well characterised transient inflammation in the small intestine which is associated with hypophagia and weight loss. This correlates with an increase in cholecystokinin (CCK) secreting enteroendocrine cells (EEC) and is under the control of CD4+ T-cells. A later secondary bout of hypophagia corresponds with the T. spiralis larvae encysting in the striated muscle, which is independent of EEC, but thought to involve inflammatory cytokines. However the mechanisms governing both these responses remain unknown.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available