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Title: Molecular analysis of clonal variaiton in GS-CHO cell lines
Author: Hazlewood, Elizabeth
ISNI:       0000 0001 3550 0601
Awarding Body: Manchester University
Current Institution: University of Manchester
Date of Award: 2006
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Therapeutic proteins are required for the treatment of a variety of chronic and life threatening diseases and as s such there is a high demand for their rapid production. Chinese hamster ovary (CHO) cells are commonly used for therapeutic protein production because they perform the post-translational modifications required for the correct biological activity in patients. However, when compared to other expression systems, recombinant CHO cell lines produce a relatively low concentration of recombinant protein. There are many studies that have improved recombinant protein production in CHO cell lines by enhancing specific productivity and viable cell density and methods have been developed to isolate high-producing cell lines at an early stage of cell line development.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available