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Title: The directed selection of recombinant human anti-testosterone antibodies and their use in immuno-modulating androgen receptor function
Author: Kenyon, Andrew Robert
ISNI:       0000 0001 3597 4479
Awarding Body: The University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2007
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Prostate cancer (PCa) is the second most common cancer in Western men; with over 30,000 new cases are diagnosed in the UK each year. Primarily treatment involves targeting the androgen-signalling pathway by blocking production of testicular androgens and/or inhibiting AR function. Current treatments depend on the age and health of the patient. These treatments range from a watch and wait strategy to androgen ablation therapy, by chemical or surgical castration, with the addition of using anti-androgens to block the AR function. The drawbacks of these treatments include loss of bone mineral density, urinary dysfunction, bowel dysfunction, erectile dysfunction, loss off libido and fertility.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available