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Title: The mode of action of daptomycin against Staphylococcus aureus
Author: Hobbs, Joanne Karen
ISNI:       0000 0001 3579 4793
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2008
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The mode of action (MOA) of the anti-staphylococcal antibiotic daptomycin is poorly understood and in the last five years, four distinct mechanisms of action have been proposed, namely K+ leakage and membrane depolarisation, inhibition of peptidoglycan biosynthesis, interaction with RNA polymerase and disruption of cell division machinery. The significance of these potential mechanisms in the lethal MOA of daptomycin is unknown, and this is addressed in this thesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available