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Title: The influence of nature and nurture on the murine gastrointestinal tract microbiota
Author: Friswell, Melissa Kathleen
ISNI:       0000 0001 3484 6387
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2007
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Commensal organisms associated with areas of the host exposed to the external environment are collectively termed the microbiota. Whilst poorly understood environmental and genetic factors influence the development of the large intestinal microbiota, the relative contributions of host genetics vs. the environment remain unknown. Faeces was selected as a paradigm for gut microflora comparison studies since 16S rRNA PCR-DGGE derived fingerprints from intestinal lumen, mucosa and faeces were highly similar. DGGE analysis of faeces from five highly inbred strains of mice housed and bred at Manchester University (C3H, C57. GFEG, CBA and CD1), showed that mice of the same strain harboured highly similar fingerprint profiles that were characteristic for each individual mouse strain.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available