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Title: Cell signalling pathways and clinical outcome of oxidative stress inhibitiors in acute pancreatitis
Author: Virlos, Ioannis Theodore
ISNI:       0000 0001 3548 5800
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Contemporary theories regard that systemic inflammatory response in acute pancreatitis is elicited by the secretion of the pro-inflammatory cytokines, leukocytes activation and their interaction with the activated vascular endothelium. There is increasing evidence of the role of acinar cell injury and oxidative stress injury as key events of localised pancreatic response in acute pancreatitis, which triggers the production of pro-inflammatory cytokines and subsequently the escalation of systemic inflammatory response and remote organ dysfunction. The aim of this thesis is to assess the role of anti-oxidant supplementation in the outcome of severe acute pancreatitis and to investigate the effect of a central inflammatory pathway inhibition in acute pancreatitis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available