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Title: The role of NFκB in glucocorticoid resistance in childhood acute lymphoblastic leukaemia (ALL)
Author: Nicholson, Lindsay
Awarding Body: Newcastle-upon-Tyne University
Current Institution: University of Newcastle upon Tyne
Date of Award: 2008
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Glucocorticoids (GC) are pivotal agents used in the treatment of childhood acute lymphoblastic leukaemia (ALL) but the molecular basis of GC-resistance remains unclear. Although mutation or loss of the glucocorticoid receptor (GR) leads to GCresistance in vitro, genetic aberration of the GR is rare in clinical samples. Expression-array studies have shown that commonly-upregulated genes associatec with GC-sensitivity include GR, glucocorticoid-induced leucine zipper (GILZ) and kBa, which negatively interact with components of the pro-survival NFkB pathway and may be critical determinants of GC-sensitivity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available