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Title: Pharmacogentic factors influencing the metabolism of 13-cis retinoic acid
Author: Rowbotham, Sophie E.
ISNI:       0000 0001 3538 5201
Awarding Body: Newcastle University
Current Institution: University of Newcastle upon Tyne
Date of Award: 2008
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5203 L $$aThe administration of 13-cis retinoic acid (13cisRA) improves 3-year event free survival rates in children with high-risk neuroblastoma. However, more than half of patients suffer relapse within 3 years. A high degree of variability in UcisRA pharmacokinetics has been reported, suggesting that individualisation of dosing may further improve therapy. Several cytochrome P450 (CYP) and UDPglucuronosyltransferase (UGT) enzymes play a role in the metabolism of retinoic icid. Thus, genetic variation in CYP and UGT activity could underlie the individual differences in 13c/5RA metabolism and bioavailability.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available