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Title: Angiogenesis in colorectal tumours : a therapeutic target?
Author: Johnson, A. S.
ISNI:       0000 0001 3590 9765
Awarding Body: Newcastle University
Current Institution: University of Newcastle upon Tyne
Date of Award: 2008
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Development of solid tumours depends on new vessel formation by angiogenesis. Angiogenic endothelial cells (ECs) express different genes compared with quiescent ECs. Evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin protect against bowel cancer. Multiple mechanisms may be responsible, but aspirin may target angiogenic tumour ECs. The aims of this project were firstly, to monitor NSAID effects on angiogenesis, and determine if this was by cyclooxygenase inhibition, and secondly to investigate novel genes expression in tumour ECs to identify targets for anti-angiogenic cancer therapy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available