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Title: The molecular mechanisms of calicivirus-induced apoptosis
Author: Brennan, Benjamin
ISNI:       0000 0001 3478 5844
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 2008
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The Caliciviridae family are a group of small, non-enveloped viruses that contain a single stranded positive sense RNA genome approximately 7.5 kb in size. Several members of this virus family are significant pathogens of both animals and man. Perhaps the most well known member is Norovirus, which is reported to be the leading cause of viral gastroenteritis worldwide (approx. 95% of cases). Despite this, the molecular effects of the virus on host cells and pathogenicity of the disease has not been well reported due to the inability to grow most of these viruses in cell culture. Two members of the Calciviridae,, however, have been shown to replicate efficiently in certain cell lines. For this reason, these viruses are being used as models to study virus/host interactions. The aim of this project was to (i) further characterise the molecular mechanisms of FCV-induced apoptosis by examining the events that occur upstream of bax translocation to the mitochondria; (ii) examine the molecular mechanisms of apoptosis occurring during infection of CRFK cells with virulent systemic disease causing isolates of FCV and (iii) perform preliminary investigations into the mechanism of cell death occurring during MNV-1 infection.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available