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Title: A role for the Rac GEF, STEF, in cell migration, polarization and Ras-induced transformation.
Author: Rooney, Claire
ISNI:       0000 0001 3534 7854
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Tiam1 (for T-lymphoma invasion and metastasis-inducing protein) belongs to the Rho GEF family of proteins. In response to growth factors and cell-substrate interactions, Tiam1 selectively activates Rac. Using a two stage chemical carcinogenesis protocol (DMBA/TPA) it was previously shown that mice lacking Tiam1 are resistant to the development of Ras-induced skin tumours, suggestmg an important role for Tiam1/Rac signalling in tumourigenesis in vivo.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Skin cancer