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Title: The regulation of Langerhans' cell function in health and disease.
Author: Scheider, Laura
ISNI:       0000 0001 3554 9413
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Langerhans' cells (LC) are the dendritic cells (DC) found in the epidermis, where they serve as sentinels of the skin immune system. Langerhans' cells recognise, internalise and process foreign antigen and transport it from skin to the lymph node (LN), where immune responses are initiated. Here, skin biopsies were obtained from volunteers before and 24 h after exposure to the Trier social stressor. Epidermal LC frequencies appeared significantly reduced 24 h after exposure to the stressor, suggesting an important role for LC in the modulation of skin immune responses by acute psychosocial stress. Taken together, these results suggest that LC function plays an important role in the generation and regulation of the skin immune response, and the modulation of LC frequencies and function by environmental and intrinsic factors may have relevance to the natural history of skin inflammatory disease.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available