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Title: The in vivo role of integrin alpha7 in heart integrity and function.
Author: Nadif, Raja
ISNI:       0000 0001 3438 8742
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2007
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Cardiovascular complications, including cardiac hypertrophy, arrhythmias and sudden death, are commonly associated with muscular dystrophies. Null mutations of the integrin alpha? gene, an essential mediator of cellular attachment to the extracellular matrix in cardiac and skeletal muscle, leads to progressive muscular dystrophy in humans, which is faithfully replicated in the integrin alpha? deficient (a7-/-) mouse model. In the latter, premature sudden death is not directly attributable to the dystrophic phenotype. We therefore analysed the cardiac phenotype in integrin a7-/- mice to determine whether their premature death is associated with altered cardiac structure and function and/or altered cardiac rhythm.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available