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Title: Investigation of Genetic Variation within the TNF Signalling Pathway in Disease Susceptibility and Anti-TNF Treatment Response in Patients With Rheumatoid Arthritis.
Author: Potter, Catherine
ISNI:       0000 0001 3496 9686
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2007
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Rheumatoid arthritis (RA) is a chronic inflammatory joint disease, which affects -1% of adults in the developed world. Although the aetiology is poorly understood, it is clear that the proinflammatory cytokine tumour necrosis factor (TNF) plays a pivotal role in regulating the persistent inflammation characteristic of this disease. This is exemplified by the success of antiTNF therapy in many patients with RA. However, treatment with these agents is limited by expensive annual costs while a substantial, yet unpredictable, proportion of patients receive no clinical benefit.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available