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Title: Intracellular delivery of MDR drugs
Author: Zheng, Zhaohua
ISNI:       0000 0001 3577 6325
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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One of the most important mechanisms for multidrug resistance (MDR) phenotype is believed be the P-gp-mediated drug efflux. The consequent lowering of the intracellular concentrations of many commonly-used chemotherapeutic drugs, such as doxorubicin (Dox), has been addressed by P-gp inhibition via covalent attachment of MDR drugs to carriers.This project aimed to develop new drug binding peptide structures able to traverse cell membranes and to investigate their potential in the 'non'-covalent' deiivery of Dox in drug-resistant (KD30) cells.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available