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Title: Characterising the role of WASP family protein phosphorylation
Author: Pocha, Shirin
ISNI:       0000 0001 3493 2103
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2008
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The WASP family of proteins plays a pivotal role in the cell, integrating signals from extracellular stimuli to generate dynamic changes in the actin cytoskeleton. The WASP family of proteins consists of three subfamilies; the WASP subfamily which contains the haematopoietically expressed WASP and its ubiquitously expressed homologue N-WASP, the WAVE subfamily comprising WAVE1-3, and the recently identified WASH subfamily. All three sub-families contain a C-terminal VCA domain, through which they nucleate actin polymerisation via activation of the Arp2/3 complex. Regulation of WASP family proteins differs between sub-families, however a rapidly emerging theme in the WASP and WAVE sub-families is regulation by phosphorylation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available