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Title: Understanding brainstem microvessels in hypertension
Author: Toward, Marie Ann
ISNI:       0000 0001 3535 6507
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2008
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Hypertension is associated with autonomic nervous system dysfunction. Elevated sympathetic outflow and alterations in the baroreceptor reflex sensitivity may play an important role in the initiation and maintenance of high blood pressure. Previous work from this laboratory has demonstrated that endothelial derived genes are differentially expressed in key brainstem nuclei in hypertensive rats. In addition, angiotensin II acting at the nucleus tractus solitarii has been shown to attenuate the baroreflex through a vascular-neuronal signalling mechanism involving the release of nitric oxide. This evidence has led to the hypothesis that alterations in brainstem microvascular gene expression are causative to hypertension in animals and man.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available