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Title: Host-commensal interactions in the human upper respiratory tract: the mucosal immune response to Neisseria lactamica and Neisseria meningitidis
Author: Vaughan, Andrew
ISNI:       0000 0001 3543 3277
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2008
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The human upper respiratory tract is colonised by a diverse commensal flora that is tolerated by the host without inducing an aberrant inflammatory response. N. meningitidis is an opportunistic pathogen that asymptomatically colonises the nasopharyngeal epithelium of older children and adults, but infrequently causes invasive disease. N. lactamica is a closely related commensal that colonises the nasopharyngeal epithelium of young children without causing disease. Both species can colonise for prolonged periods without being cleared. We have Investigated the development of mucosal immunity to N. lactamica and compared the response with N. meningitidis to further understand how each maintains a commensal relationship with the host.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available