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Title: Regulation of uterine contractility by small GTP binding proteins
Author: Lartey, Dr Jonathan Paul Akueteh
ISNI:       0000 0001 3605 2839
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2007
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Uterine smooth muscle contraction is determined by the state of myosin (MYL) phosphorylation which is regulated by the calcium dependent myosin light chain kinase (MYLK) and a protein phosphatase called myosin phosphatase. Agonist induced increases in intracellular calcium ([Ca²⁺]i)activates MYLK which phosphorylates MYL enabling it to bind to actin to cause contraction. Myosin phosphatase is a protein phosphatase that dephosphorylates phosphorylated MYL to induce relaxation. The state of MYL phosphorylation and contraction is therefore determined the equilibrium between MYLK and myosin phosphatase. The mechanisms that regulate these two enzymes in the human uterus remain poorly understood.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available