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Title: Diagnosis of lung cancer by raman spectroscopy.
Author: Maltt, N. D.
ISNI:       0000 0001 3617 7543
Awarding Body: Queens University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
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lung cancer patients from 'at risk' controls and 'at risk' control subjects from healthy control subjects. Porphyrin-containing substances were higher in the 'at risk' controls than either the healthy controls or the lung cancer patients. Additionally the induced sputum from the three groups was analysed using Surface-enhanced Desorption-Ionization Time-of-flight mass spectrometry which also distinguished the three groups. A mini fibre optic probe was used in conjunction with shifted subtracted Raman spectroscopy to analyse normal and malignant ex vivo lung tissue from 7 patients, obtained from lung cancer surgical resections and could classify the two types of tissue perfectly. In conclusion, Raman spectroscopy has the potential to diagnose lung cancer, predict prognosis and elucidate the chemical changes associated with carcinogenesis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available