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Title: The control of motor function in invertebrate parasites of animals as a endectocide target.
Author: Veal, E. R.
ISNI:       0000 0001 3544 6270
Awarding Body: Queens University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
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Parasite and pest populations cause huge terpls of econo~ic loss and human and animal welfare.. Currently control strategies rely heavily on chemotherapeutics. However resistance to these is increasing and becoming a matter of increasing concern. There is therefore a need for the development ofnew drugs and information is also needed on parasite biology and how current anthelmintics exert their effects. A selection ofcurrent anthelmintics were tested to examine their effects on the reproductive systems ofAscaris suum (a nematode) and Schistocerca gregaria (a locust). All anthelmintics tested apart from one were able to modulate the contractility ofthe ovijector in A. suum. Ivermectin was the only anthelmintic which was active on both systems and appeared to have a novel mode of action on the ovijector ofA. suum. A selection ofnematode neuropeptides (FLPs and NLPs) were tested for inter-phyla activity on the oviduct ofS. gregaria and the ovijector ofA. suum. It was foundthat FLPs had a superior activity on both systems compared to the NLPs and as ~uch the FLP receptors for the most potent peptides identified in this study have potential as novel endectocide targets. Immunocytochemistry studies also revealed that FLPs have a more widespread distribution in the nematode nervous system than NLPs. Evidence for the presence of a muscarinic signalling system in the . ovijector ofA. Slilim was found by.physiological studies and molecular techniques and may also have potential as a target for novel drugs.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available