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Title: In vitro folding and assembly of the E.Coli ABC transporter BTUCD
Author: Bartolo, Natalie Di
ISNI:       0000 0001 3423 3281
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2008
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Most studies of membrane protein folding have focused on a-helical monomeric proteins. The next major challenge is to extend these folding studies to incorporate oligomeric membrane proteins, for which there is a paucity of information available on their folding and assembly. The folding of multisubunit proteins is a biologically important and far-reaching area of research since the majority of proteins exist as protein-protein complexes. In order to understand these proteins it is important to be able to recreate their folding and assembly in vitro starting with simple model protein complexes. Work in this thesis takes advantage of the modular organisation of BtuCD and methods are described to prepare the individual building blocks of the protein complex.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available