Use this URL to cite or link to this record in EThOS:
Title: Cytokine gene polymorphism in non-infectious uveitis
Author: Atan, Deniz
ISNI:       0000 0001 3431 476X
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2008
Availability of Full Text:
Full text unavailable from EThOS. Restricted access.
Please contact the current institution’s library for further details.
Non-infectious uveitis is a blinding intraocular inflammatory disorder with an autoimmune pathogenesis. Like other autoimmune diseases, uveitis has multifactorial and polygenic aetiology. The results of this study have shown that polymorphisms of the ILIO and TNF genes influence the susceptibility and seventy of uveitis. These polymorphisms were either known to correlate with altered transcription levels, or linked with other polymorphisms positioned within regulatory conserved non-coding sequences. Thus the identification of specific genetic variants that confer susceptibility or resistance to uveitis has provided insights into the pathogenesis of uveitis, and might allow the prediction of patients who will have aggressive disease to allow tailoring of treatment to the individual.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available