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Title: Heterologous regulation of ADP and thromboxane receptors on human platelets
Author: Barton, Johanna F.
ISNI:       0000 0001 3449 8386
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2008
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Thromboxane A2 (TXA2) and ADP are both major positive feedback mediators of platelet activation and act through G-protein coupled receptors (GPCRs) on the platelet surface. Aspirin and clopidogrel, two of the main drugs used in the prevention of acute coronary syndromes, function by blocking the actions of these two agonists at their receptors. Since aspirin and clopidogrel have been shown to be more effective when administered together rather than alone, the study of potential cross-talk between TXA2 and ADP receptors (TP and P2Y) is important in improving understanding of the combined mechanism of action of these two drugs.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available