| Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492108 |
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| Title: | Role of mitogen-activated protein kinases in the synergenic induction of matrix metalloproteinase-1 and - 13 following Interleukin-1- and Onconstatin M stimulation | ||||
| Author: | Jefferson, Matthew |
ISNI:
0000 0001 3589 7370
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| Awarding Body: | University of Newcastle upon Tyne | ||||
| Current Institution: | University of Newcastle upon Tyne | ||||
| Date of Award: | 2008 | ||||
| Availability of Full Text: |
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| Abstract: | |||||
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One of the major characteristics of both rheumatoid and osteoarthritis is aberrant matrix metalioproteinase (MMP) -1 and -13 induction leading to irreversible cartilage breakdown. MMP-1 and 13 induction is known to be mediated by interleukin -1 (IL-1) within the arthritic joint, furthermore it is also known that oncostatin M (OSM) potentiates the effects of IL-1 in a synergistic manner. Although the phenomenon of synergy with IL-1+0SM is well documented, little data exist explaining the precise underlying mechanism.
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| Supervisor: | Not available | Sponsor: | Not available | ||
| Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
| EThOS ID: | uk.bl.ethos.492108 | DOI: | Not available | ||
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