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Title: Role of mitogen-activated protein kinases in the synergenic induction of matrix metalloproteinase-1 and - 13 following Interleukin-1- and Onconstatin M stimulation
Author: Jefferson, Matthew
ISNI:       0000 0001 3589 7370
Awarding Body: University of Newcastle upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2008
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One of the major characteristics of both rheumatoid and osteoarthritis is aberrant matrix metalioproteinase (MMP) -1 and -13 induction leading to irreversible cartilage breakdown. MMP-1 and 13 induction is known to be mediated by interleukin -1 (IL-1) within the arthritic joint, furthermore it is also known that oncostatin M (OSM) potentiates the effects of IL-1 in a synergistic manner. Although the phenomenon of synergy with IL-1+0SM is well documented, little data exist explaining the precise underlying mechanism.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available