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Title: Computed radiography in the quantification of bone content and morphology in the healing tibial shaft
Author: McCann, Aaron Jude
ISNI:       0000 0001 3622 7766
Awarding Body: Queen's University of Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
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Image processing techniques have been devised which allow quantitative measurements of bone mineral density (BMD) and soft tissue content from clinical, single-energy Computed Radiography (CR) radiographs. Impediments to quantitative data extraction and serial comparison have been addressed, specifically the physical phenomena associated with X-ray irradiation (scatter, beam hardening, spatial beam inhomogeneity), the automated processing and digitization of the image by the CR processing unit, and variation in patient positioning between visits. Interactive image processing software has been developed which allows automated processing of clinical lower leg radiographs and extraction of serial BMD measurements at user defined regions of clinical interest. Output may be visualized in the form of absolute BMD images, colour subtraction images, time-lapse animations and parametric images. The techniques have been applied to a group of tibial shaft fracture patients treated with intramedullary nailing and llizarov frame fixation. Analysis of BMD and soft tissue content in serial images has identified significant differences in the quantities and patterns of tissue generation and loss at the fracture site and local regions. The technique has the potential to complement existing radiological methods in fracture review and other areas of study, and for use in clinical research.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available