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Title: Studies on the diagnosis and pathogenesis of animal virus infections
Author: Adair, Brian McConnell
ISNI:       0000 0001 3393 2339
Awarding Body: Queen's University of Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
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This thesis contains a collection of selected published works which cover studies on the diagnosis and pathogenesis of three groups of viruses which cause significant disease in farmed animals. The initial part of the work covers studies on avian and mammalian adenoviruses. A number of newly isolated adenoviruses from several species were classified by comparison with recognised strains and their basic properties, including growth and development in cell cultures were investigated. Diagnostic tests, particularly tests to detect anti-viral antibodies were developed and standardised. The characterisation studies were successful in identifying subgroups of adenoviruses which behaved differently from the conventional viruses, or were unusual in some of their 'properties. Several of the viruses characterised in the thesis (egg 'drop syndrome virus, ovine adenovirus 287, and the bovine adenovirus types 4, 5, 6, 7, and 8) were shown to be sufficiently different to warrant separation into a separate Adenovirus genus' (Atadenovirus). Studies on the Circoviruses and Paramyxoviruses w~re aimed at elucidating the effects of the viruses on immune function, and the role of various immune cell populations in combating the infection. Investigations with the avian circovirus, chicken anaemia virus, showed that the virus selectively infected and destroyed precursor T cells in the thymus of the chicken, as well as myeloid precursors in the bone marrow. The effects of the virus on lymphocyte and macrophage functions, leading to a profound immunosuppression was documented, and the mechanisms by which the virus caused disease was clarified. The studies on parainfluenza type 3 virus (PI3V) concentrated on the ability of various leukocyte populations (granulocytes, macrophages and lymphocytes) to selectively kill Pl3V-infected cells. These investigations provided a picture of the innate and acquired cellular responses which come into effect following infedion of the lower respiratory tract. Supplied by The British Library - 'The world's knowledge'
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Sc.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available