Use this URL to cite or link to this record in EThOS:
Title: The prevalence and risk factors of abdominal aortic aneurysm in Northern Ireland.
Author: Badger , Stephen Andrew
ISNI:       0000 0001 3435 1042
Awarding Body: Queen's University of Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
Availability of Full Text:
Full text unavailable from EThOS.
Please contact the current institution’s library for further details.
Abdominal aortic aneurysms (AAA) occur in about 5% of men at the age of 65 years. Mortality from rupture is approximately 90% and screening has been suggested as a means to reduce the risk of rupture by early detection and treatment.Men from the community and cardiology clinics aged 65-75 years were invited to attend for AAA screening, as well as first-degree relatives of previous patients. Demographic and medical details were collected from all participants. Serum and whole blood was collected fromAAA cases and controls.After inviting 4500 to participate in the screening, the attendance was found to be higher in less deprived areas and in higher-risk groups of individuals. Disease prevalence was highest (9.8%) in those attending the cardiology clinics. It was also influenced by smoking and deprivation. It was unexpectedly low in AAA patients' relatives at 3.3%. Cotinine and C-Reactive Protein were tested in the serum by an ELISA test. Human Leucocyte Antigen genetic distribution was assessed in HLA-A, -8 and -DR. The most functionally important single nucleotide (SNP) of the CRP gene, in addition to 2 CQX-2 and 3 Fibulin-5 SNPs were assessed. Cotinine and CRP were higher in AAA patients compared to controls. Concentrations of CRP were also higher in patients with larger aneurysms. This was not influenced by genetic polymorphisms of the CRP or CQX-2 genes. No differences were found in genotype distribution in the CRP, CQX-2 and Fibulin-5 important polymorphisms. HLA-A, -8 and -DR allele family distributions were also similar between cases and controls. AAA is a multifactorial disease with no genetic causal link identified in the genes studied.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available