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Title: Characterisation of Connexin-Mediated Communication in the control of epidermal stem cell fate
Author: Easton, Jennifer Anne
ISNI:       0000 0001 3437 2433
Awarding Body: Glasgow Caledonian University
Current Institution: Glasgow Caledonian University
Date of Award: 2009
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Connexins (Cxs) are believed to play a significant role in the control of cellular events such as cell proliferation and differentiation. The overall aim of the present work was to determine if modification of Cx expression and/or function altered the commitment of cells to either enter the differentiation pathway or stay in a proliferative state. Two Cx modification agents, GAP27 and AAPIO, and a novel murine epidermal stem cell model were employed as investigative tools in this study. The development of the novel mouse model was examined under control condition and following modification of Cxs to determine the role of Cxs in controlling cell proliferation and differentiation events.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available