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Title: Regulation of glucocorticoid receptor activity by a stress responsive transcriptional cofactor
Author: Davies, Laura
ISNI:       0000 0001 2451 2359
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor, involved in the regulation of metabolism, inflammation, the immune response and stress response. GR is a member of the nuclear hormone receptor superfamily and is activated by binding glucocorticoids, which triggers receptor dimerisation, nuclear translocation and transcriptional activity. The activity of GR is further modulated by post-translational modifications, cofactor recruitment and protein stability. Exactly how GR regulates transcriptional activity in a gene specific manner and how GR responds to cellular stress is unclear.University of Manchester.
Supervisor: Krstic-Demonacos, Marija Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available