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Title: Parental occupational exposure and risk of childhood cancer
Author: Raji, Olaide Yaqeen
ISNI:       0000 0001 3505 850X
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2008
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The risk of childhood cancer has been inconsistently linked with parental exposure to occupational agents, partly because of poor exposure assessment. Data from the UK Childhood Cancer Study,. a nationwide population based case-control study, was used to extend previous analyses ofparental occupational exposures assessed via job and industry titles. Eight specific work related exposures were examined as possible risk factors for childhood leukaemia and lymphoma for three exposure time windows (preconception, pregnancy, postnatal). Personal interview data from parents of cases and matched controls included a full occupational history; for each job where exposure had been indicated, detailed information was gathered on each reported exposure agent. A new exposure assessment method was designed, which scrutinised five exposure determinants to provide semi-quantitative indices on exposure probability, level of exposure, frequency of contact, and degree of protection. These were combined to derive a final 'reviewed' exposure status. The method was externally validated against an independent expert assessment. Multivariable unconditional logistic regression estimated odds ratios and 95% confidence intervals for 'self-reported' and 'reviewed' exposures. Mothers had a lower prevalence of exposure (18%) compared· to fathers (44%). The 'reviewed' exposure status reclassified 33% of 4833 mothers' and 50% of 19,326 fathers' reported job exposures as 'exposed'. Many statistically significant risks for 'self-reported' exposure disappeared when applying the reclassified exposure. Only maternal exposure to solvents during pregnancy remained statistically significantly associated with acute lymphoblastic leukaemia (ALL) (OR=2.7, C.I=1.6-4.6) with evidence of a dose-response relationship. Paternal exposure to fertilisers during pregnancy and postnatally also remained statistically significantly associated with ALL and Hodgkin Lymphoma but without evidence of dose-response relationships. The designed exposure assessment method represents a novel approach for evaluating parental occupational exposure for use in future studies. The findings for mothers for the generic group of solvents warrants further independent research. Overall, findings must invoke caution in the interpretation of risk estimates reliant on 'selfreported' occupational exposure in epidemiological investigations.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available