Use this URL to cite or link to this record in EThOS:
Title: The Neurobiology of Intertemporal Choice
Author: Campbell, Thomas
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2007
Availability of Full Text:
Full text unavailable from EThOS.
Please contact the current institution’s library for further details.
Intertemporal choices are both common and important and yet the neurobiology of intertemporal choice is poorly understood. The work in this thesis contributes to a growing literature on the neurobiology of intertemporal choice. In particular I have investigated the contributions of the orbitofrontal cortex (OFC) and hippocampus (HPC) to intertemporal choice through the creation of novel intertemporal choice behavioral tasks. Firstly I reported that lesions of the HPC, but not the OFC, cauSe impulsive choice in a non-spatial T-maze based behavioral task. Secondly I described the creation and validation of a spatial, T-maze based intertemporal choice task for mice. This task was then used to investigate the contributions of the dopaminergic and serotonergic systems to intertemporal choice in mice. These experiments suggested that the dopaminergic system, but not the serotonergic system, is important in intertemporal choice. I then examined the contributions of the mouse OFC and HPC to intertemporal choice using an operant intertemporal choice task for mic.e. In this task, lesions of the HPC, but not the OFC, cause an increase in self- . controlled choice. Finally I reported a series of modelling experiments exploring the adaptiveness of self-control in foraging. These experiments called into question an influential theory suggesting that interspecific differences i~ metabolic rates helped .drive the evolution of impulsive strategies.. ' The behavioral tasks developed in this thesis may be used to further our understanding of the neurobiology of intertemporal choice and in particular the genetic basis of intertemporal choice.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available