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Title: The role of the noradrenergic system in cognition and neuroinflammation
Author: Scullion, Gillian Ann
ISNI:       0000 0001 3391 689X
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2008
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Alzheimer's disease (AD) is characterised by cognitive dysfunction and the appearance of Β-amyloid plaques (Ap), localised neuroinflammation and neuronal loss throughout the brain. These features are predominantly found in regions important to cognitive function such as the frontal cortex (FC) and hippocampus. The locus coeruleus (LC) is a main source of noradrenaline (NA) in the brain and released NA plays an important role modulating cognitive processes and may also regulate the inflammatory response. LC degeneration is apparent in the early stages of AD, as are decreased NA concentrations in LC projections regions. The relationship between NA dysfunction and AD pathogenesis remains unclear.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available