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Title: Studies on a Series of Polymeric and Monomeric Salen Superoxide Dismutase/Catalase Mimics
Author: Keenan, James Michael
ISNI:       0000 0001 3596 3083
Awarding Body: University of York
Current Institution: University of York
Date of Award: 2008
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In this study a series of polymeric and monomeric salen ligands based on 2,5-dihydroxybenzaldehyde (G) and 2,4-dihydroxybenzaldehyde and also the complexes of these ligands with various transition metals have been synthesised and characterised. The aim of this project was to investigate the electrochemistry of these complexes and their ability to mimic the activity of superoxide dismutase (SOD) and catalase (cat). All monomeric complexes produced were first tested in order to observe whether they possessed any redox chemistry. This testing was undertaken using cyclic voltammetry and it was discovered that all complexes, including those of redox inactive metals, displayed some redox processes in the potential window for superoxide dismutation and those of Mn and Co also displayed processes within the window for the dispropotionation of hydrogen peroxide. Using the xanthine/xanthine oxidase assay with XTT as the indicator the SOD mimetic activity of the complexes was probed. It was found that monomeric and polymeric complexes of each metal tested, Mn, Co, Fe, Ni and Zn, were active with the redox active metal complexes showing much greater activity than those of the redox inactive metals. Owing to the fact that monomeric catalysis was homogeneous and. polymeric was heterogene~us, monomeric complexes all showed activity which was higher than that of the polymeric species by a factor between 10 and 100. Finally, the cat mimetic ability was tested using a gas displacement cell. This setup monitors the evolution of oxygen from a reaction and therefore can be used, on comparison with known activities of catalase, to assess the activity of mimics. The results showed that once again complexes of each metal showed some activity with, as expected from the electrochemical data, Mn and Co displaying much higher activity than those of Fe, Ni and Zn and monomeric species showing higher activity than the polymeric complexes for the reasons given above.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available