| Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490456 |
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| Title: | Redox regulation through S-thiolation and S-nitrosylation of the BCAT proteins with insights in to the role these systems play in neuronal cells | ||||
| Author: | Coles, Steven John |
ISNI:
0000 0001 3560 3109
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| Awarding Body: | University of West of England, Bristol | ||||
| Current Institution: | University of the West of England, Bristol | ||||
| Date of Award: | 2008 | ||||
| Availability of Full Text: |
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| Abstract: | |||||
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The human mitochondrial and cytosolic branched chain aminotransferases (hBCATm and hBCATc, respectively) are key metabolic enzymes that catalyse the reversible transamination of the nutritionally essential branched-chain amino acids. Both isozymes have a conserved redox active CXXC motif, unique among the mammalian aminotransferases. In the present study the effect of ^S-nitrosylation, iS-thiolation or disulphide bond formation on the functionality of the BCAT proteins was investigated.
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| Supervisor: | Not available | Sponsor: | Not available | ||
| Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
| EThOS ID: | uk.bl.ethos.490456 | DOI: | Not available | ||
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