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Title: Aspects to T-cell phenotype during infection with HIV, CMV and Hepatitis C virus
Author: Northfield, John
ISNI:       0000 0001 3449 7391
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2008
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This work concerns itself with understanding the organisation of cellular immune responses to three major human pathogens - HIV, CMV and Hepatitis C (HCV). Each was studied to form three projects, each undertaken with a different approach - arrived at independently - and largely owing their origins to opportunity and circumstance as much as design. Each project led to exploration of a particular aspect of T-cell phenotype (that is the expression of particular molecular markers on T-cells) and its’ broader biological significance. I found that T-cell phenotype was strongly linked to the magnitude of T-cell responses (CMV) and the ability of T-cells to control infection (HIV). Finally I explored the significance of expression of a molecule known as CD161 on the surface of HCV specific CD8+ T-cells, indicating a phenotype of T-cell that may not follow the ‘normal rules’ applicable to T-cells in general.
Supervisor: Klenerman, Paul Sponsor: Wellcome Trust
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biology ; Cell Biology (see also Plant sciences) ; Microbiology ; Biology and other natural sciences (mathematics) ; Immunology ; Infectious diseases ; Hepatitis C ; T-cell ; virus ; immunity