Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490260 |
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Title: | Design, synthesis and biological evaluation of heparin/heparan sulfate analogues as inhibitors of GAG-growth factor interaction | ||||
Author: | Raiber, Eun-Ang |
ISNI:
0000 0001 3505 5341
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Awarding Body: | University of Salford | ||||
Current Institution: | University of Salford | ||||
Date of Award: | 2007 | ||||
Availability of Full Text: |
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Abstract: | |||||
Control of cell proliferation is of fundamental importance to cancer chemotherapy. One of the key signalling events leading to cellular activities (i.e. cell division, proliferation, migration) involves Growth Factors such as Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and Fibroblast Growth Factors (FGFs). They bind to specific transmembrane tyrosine kinase receptors at the cell surface. This can only take place in the presence of heparin and heparan sulfate proteoglycans. The literature in this area is reviewed.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.490260 | DOI: | Not available | ||
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