Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490110 |
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Title: | Separation control in over-expanded supersonic nozzles | ||||
Author: | Marrion, Maynard |
ISNI:
0000 0001 3619 284X
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Awarding Body: | University of Oxford | ||||
Current Institution: | University of Oxford | ||||
Date of Award: | 2008 | ||||
Availability of Full Text: |
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Abstract: | |||||
Needle-free drug and vaccine delivery devices have been developed by the Department of Engineering Science at The University of Oxford in collaboration with PowderJect Pharmaceuticals plc. In them, micro-particles of pharmaceuticai agent are accelerated, by a supersonic flow of gas in a nozzle, to velocities sufficient for them to penetrate the outer layers of the skin. If the gas flow is over-expanded relative to the atmosphere to which it discharges, shock waves form inside the nozzle, which cause the flow to separate from the wall. The resulting gas-particle flow field is highly non-uniform, leading to suboptimal drug or vaccine delivery and even damage to the target skin.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.490110 | DOI: | Not available | ||
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