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Title: Separation control in over-expanded supersonic nozzles
Author: Marrion, Maynard
ISNI:       0000 0001 3619 284X
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2008
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Needle-free drug and vaccine delivery devices have been developed by the Department of Engineering Science at The University of Oxford in collaboration with PowderJect Pharmaceuticals plc. In them, micro-particles of pharmaceuticai agent are accelerated, by a supersonic flow of gas in a nozzle, to velocities sufficient for them to penetrate the outer layers of the skin. If the gas flow is over-expanded relative to the atmosphere to which it discharges, shock waves form inside the nozzle, which cause the flow to separate from the wall. The resulting gas-particle flow field is highly non-uniform, leading to suboptimal drug or vaccine delivery and even damage to the target skin.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available