Use this URL to cite or link to this record in EThOS:
Title: Mechanisms of cardiac pleiotrophy in cited 2 dificiency
Author: MacDonald, Simon T.
Awarding Body: Oxford
Current Institution: University of Oxford
Date of Award: 2008
Availability of Full Text:
Full text unavailable from EThOS.
Please contact the current institution’s library for further details.
How can a single gene defect present with a varied phenotype- Cited2 gene deletion in the mouse results in pleiotropic, penetrant and variable cardiovascula malformations, laterality defects, adrenal agenesis, neural tube defects and fused cranial ganglia. CITED2 acts as a transcriptional co-activator, and as transcriptional repressor of PHFIA. Loss of Cited2 has been shown to be associated with increased levels of Vegf-a, a HIFIA target, and reduced levels of the key left-right patteming genes Nodal, Pitxlc, Leftyl in the left lateral piate mesoderm, and Pitx2c in the heart.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available