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Title: Spatial organization and segregation of the Escherichia coli chromosome
Author: Lui, Xun
ISNI:       0000 0001 3613 8536
Awarding Body: Oxford
Current Institution: University of Oxford
Date of Award: 2008
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The chromosome of a slowly-growing E. coli cell has a previously unappreciated level of spatial organization. By analyzing the localization patterns of multiple segregated genetic loci and locus pairs in fixed cells, I demonstrated that the left (L) and the right (R) replichores of the circular chromosome locate to opposite halves of each daughter chromosome with 1 replication origin (oriC) in the middle. Furthermore, loci on each replichore locate in a linearmannerfromonCto one of the chromosome edge, roughly recapitulating their genetic positions on the genome map.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available