Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490093 |
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Title: | The Roles and Interactions of the N-terminal Domains of Cardiac Myosin Binding Protein-C | ||||
Author: | King, Katie |
ISNI:
0000 0001 3599 7910
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Awarding Body: | Oxford | ||||
Current Institution: | University of Oxford | ||||
Date of Award: | 2008 | ||||
Availability of Full Text: |
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Abstract: | |||||
Myosin Binding Protein-C (MyBP-C) is a multi-domain protein located on the thick filaments of striated muscle. Mutations in the gene encoding the cardiac isoform of the protein, cMyBP-C, are known to cause hypertrophic cardiomyopathy (HCM). cMyBP-C is composed of 11 globular domains, eight of which have homology to Igl, the other three to fibronectin III. The N-terminal region of the protein has been assigned a role in the regulation of muscle contraction through its interaction with the Subfragment-2 (S2) portion of myosin.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.490093 | DOI: | Not available | ||
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