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Title: From merlin to tumourigenesis- the role of GTPases
Author: Flaiz, Christine
ISNI:       0000 0001 3468 2044
Awarding Body: University of Exeter
Current Institution: University of Exeter
Date of Award: 2008
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Rac1, Cdc42 and RhoA are small RhoGTPases, molecular switches that regulate protrusion and adhesion to other cells and the extracellular matrix. The tumour suppressor merlin controls and is itself regulated by Rac1. Merlin-deficiency has been linked to many protrusive structures like lamellipodia and ruffles, defective intercellular adhesion leading to loss of contact inhibition of growth, and increased adhesion to the extracellular matrix.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available