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Title: Stucture and dynamics of high mobility group box protein 1 (HMGB1) complexd with inhibitors of its proinflammatory activity : A combined nuclear magnetic resonance and computational chemistry approach.
Author: Mollica, Luca
ISNI:       0000 0001 3414 2806
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2008
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High-mobility group box 1 protein (HMGBl) is a nuclear component, but extracellularly it serves as a signaling molecule involved in acute and chronic inflammation, for example in sepsis and arthritis. The identification of HMGBl inhibitors is therefore of significant experimental and clinical interest. We show that glycyrrhizin, a natural anti-inflammatory and antiviral triterpene in clinical use, inhibits HMGBl chemoattractant and mitogenic activities, and has a weak inhibitory effect on its intranuclear DNA binding function.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available