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Title: Synthetic and Analytical Studies of Biologically Active Compounds
Author: Mutlu, Esra
ISNI:       0000 0001 3437 7664
Awarding Body: University of Newcastle upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2004
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first part of the project aimed to access tetralone intermediates required for the benzo[f]quinazoline inhibitors of thymidylate synthase. The project focussed sibility ofusing the intramolecular Buchner reaction to devise a short route from ailable starting materials. Hence, this route to the tetralones was via Rh(II) decomposition of precursor diazoketones. The synthesis of benzoquinazolines bus routes was relatively long, problematical and not cost effective. It was found of diazoketones with Rh(II) catalysis lead to the desired tetralones in e yields (Scheme 1). 1. Synthesis of tetralones via intramolecular Buchner reaction. .e objective in the second part of the project was to develop new approaches to leosides'. The introduction of the thio functionality in place of oxygen into the gar moiety of a nucleoside is a strategy for obtaining novel, potent anticancer and agents. The elaboration of commercially available chiral starting materials into s is the approach we used.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available