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Title: Acute and prolonged creatine supplementation in humans
Author: Pittas, Georgios
ISNI:       0000 0001 3492 2108
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2006
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The present thesis aimed to: 1) optimise short-term and prolonged creatine supplementation, with regards to muscle total creatine stores; 2) investigate the effects of prolonged creatine supplementation in combination with resistance training on lean tissue mass, functional capacity and changes in gene expression associated with muscle protein metabolism. Functional capacity and body composition were measured by dynamometry, and dual energy X-ray absoptiometry. Urine was analysed for creatine and creatinine, and blood samples were analysed for creatine, creatinine and insulin. Muscle samples were analysed for ATP, free Cr, phosphocreatine, and mRNA of genes associated with muscle protein metabolism and creatine transport. It was demonstrated that short term administration of Cr with a small amount of amino acids, small amounts of protein and simple sugars (CrPAC) markedly increased serum insulin concentration and augmented whole body creatine retention similar to what is believed to be the golden formulate (creatine with a large amount of simple sugars; CrCHO). However, ingestion of CrPAC was unable to augment muscle total creatine accumulation in the medium and prolonged term. In the third study it was demonstrated that chronic resistance training in combination with creatine or CrCHO supplementation increased lean tissue mass gains compared to resistance training alone, but this was not associated with equivalent gains in isometric strength. Finally it was shown that resistance training with or without creatine supplementation affected the mRNA expression of genes known to be involved in muscle metabolism.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available