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Title: Optimisation of in vitro experimental design for human cytochrome P450 mechanisms-based inhibition
Author: Ghanbari, Fatemeh
ISNI:       0000 0001 3495 6500
Awarding Body: Sheffield
Current Institution: University of Sheffield
Date of Award: 2008
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Critical evaluation of the published literature showed that there are considerable variations in the experimental procedures and methods of data analysis used to characterise MBI. These variations may have contributed to reports of differing values of MBI kinetic parameters for a number of compounds. The influence of applying different values of MBI kinetic parameter on the predicted maximal fold reduction in in vivo intrinsic clearance is likely to be greatest for those compounds of intermediate inhibitory potency. However, such an effect also depends on the fraction of net clearance of substrate subject to MBI, and the pre-systemic exposure to the inhibitor.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available